Tissue Lysates
Cayman Chemical 11-ProstaglndIn E2 1mg
11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.{1924} 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10 to 1,000 nM which is similar to PGE2.{2052} 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.{3806}
Cayman Chemical nuregulIn1 Type I2b Extra 1mg
Source: Recombinant human C-terminal His-tagged neuregulin-1 type I-β2b extracellular domain expressed in HEK293 cells • Amino acids: 20-238 • MW: 25.3 kDa
Cayman Chemical SynthetIc KhasInIn 1mg
A steroidal glycoside with diverse biological activities; reduces the proliferation of LNCaP and T47D cancer cells (IC50s = 32.1 and 27.5 µM, respectively); inhibits TNF-α-induced nuclear translocation of NF-κB in HaCaT keratinocytes at 50 nM; decreases AST serum levels in a mouse model of carbon tetrachloride-induced liver injury at 0.1 mg/kg; topical administration reduces EAr epidermal thickness and scaling, as well as leukocyte and macrophage infiltration, in an imiquimod-induced mouse model of psoriasis at 5 mg/kg
Cayman Chemical ProcynIdIn B3 1mg
A polyphenol flavonoid dimer with diverse biological activities; inhibits Aβ42 aggregation (IC50 = 3.54 μM); destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM); reduces oxidation of linoleic acid and scavenges DPPH free radicals in cell free assays at 1 mM; inhibits hydrogen peroxide-induced production of iNOS and apoptosis in primary murine chondrocytes; reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis at 0.01 mg/kg
Cayman Chemical SynthetIc GW 9662 1mg
The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.
Cayman Chemical 9 Z 11 E 13 Z-OctadecatrIe 1mg
An ω-5 long-chain polyunsaturated fatty acid; has been found as a major component in pomegranate seed oil; binds to the AF2 domain of PPARγ (IC50 = 2.5 µM); increases PPARα and PPARγ activity in 3T3-L1 cells in a reporter assay
Cayman Chemical BB22 4hydroxyIsoquInolIn I 1mg
Differs from BB-22 structurally by having an isoquinoline ring attached at the four position instead of a quinoline attached through the eight position of the ring; intended for forensic and research applications
Cayman Chemical 10 11-dehydro CurvularIn 1mg
A natural mycotoxin that has cytotoxic activity against select cancer cell lines; activates the heat shock response, blocks TGF-β signaling, and scavenges superoxide anions
Cayman Chemical AflatoxIn M2 1mg
A natural oxidative metabolic product of the mycotoxin aflatoxin B2
Cayman Chemical C24 1 dIhydro 1DeoxycRamID 1mg
A very long-chain atypical ceramide containing a 1-deoxysphinanine (m18:0) backbone; has been found as a major 1-deoxyceramide species in MEFs following application of 1-deoxysphinganine alkyne or 1-deoxysphinanine-d3
Cayman Chemical C16 dIhydro CeramIded18 01 1mg
A precursor in the de novo synthesis of C16 ceramide; inhibits C16 ceramide-induced membrane permeabilization in rat liver mitochondria and channel formation in liposomes; biologically inactive as a single agent
Cayman Chemical 8-Iso ProstaglndIn E2 1mg
8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}